A rapamycin-loading platelet membrane hybrid liposome with anti-inflammation effect and long-lasting repair capability for acute kidney injury.

• Tác giả: Xu Cheng, Yang Li, Botao Liu, Yue Liu, Junjie Pan, Jianxin Wang, Tongyang Xu, Miaomiao Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 001.434 Experimental method
• Thông tin xuất bản: Netherlands : Journal of controlled release : official journal of the Controlled Release Society , 2025
• Bộ sưu tập: NCBI
• ID: 37976

Tóm tắt

Acute kidney injury (AKI) represents a rapid decline in kidney function, often associated with significant morbidity and mortality. Inefficient management of acute-phase inflammation and inadequate repair of established damage exacerbate AKI and facilitate its progression to chronic kidney disease (CKD). Platelet membrane (PM) has emerged as a promising targeting ligand in various studies. PM proteins can also facilitate the recruitment and differentiation of CD34