Development of direct C-3 difluoromethylation reaction for application in synthesis of quinoline-related drugs

• Tác giả: John Nielsen, Tung Truong Thanh
• Ngôn ngữ: eng
• Thông tin xuất bản: Vietnam Journal of Science, Technology and Engineering - C, 2024
• Mô tả vật lý: tr.53
• Bộ sưu tập: Metadata
• ID: 380236

Tóm tắt

Fluorine holds a prominent position within the realm of drug discovery and development, substantiated by its presence in approximately 25% of drugs approved by the US Food and Drug Administration (FDA). Consequently, the advancement of new fluorination reactions stands as a pivotal area in medicinal chemistry...