In the time of globalization and global climate change, transformative and transgressive learning (T-learning) has been considered as a strong dynamic and an effective tool to speed up the transformation to sustainability in places that are vulnerable to impacts of climate change. Therefore, under the support and finances of UNESCO Paris ISSC (International Social Science Committee) researchers from nine countries (South Africa, Netherlands, Sweden, Vietnam, India, Ethiopia, Zimbabwe and Malawi) have co-engaged to carry out a research project called “Transformative learning for the social-ecological sustainability in times of climate change” funded by the ISSC of UNESCO Paris. The aims of the project are to investigate the nature, qualities, contribution and effect of transformative learning for sustainability at niche levels where wicked problems arise at the nexus of climate-water-food-energy-social justice. Transformative learning in the Mekong Delta of Vietnam has been chosen as a case study of this project. This article describes investigations about transformative learning in the VACB model (V Garden-A Pond- C Cage-B Biogas) in My Khanh Commune, Can Tho outskirts and outlines some important findings about T-learnings and its contributions to the formation and development of sustainable livelihood models for climate change adaptation in Can Tho.