In recent years, improving the quality of teaching and learning courses of political theories in general and Marxist-Leninist political economics in particular has received great attention, especially since the Decision No. 4890/QD-BGDDT was issued on December 23, 2019, which approved the programs and textbooks of political theory subjects for general use for university-level training in non-political theory majors. The research and teaching the courses has also been observed from many views, based on practical experiences to meet the country’s development requirements. Accordingly, thí article is to present and discuss some issues about the innovation of teaching methods for the Marxist-Leninist Political Economics courses at the University of Medicine and Pharmacy, Thai Nguyen University.