Recently, surface water of the Dong Nai river basin has been influencedby socio-economic development activities, so river water quality is reduced. Theauthor used a number of methods such as collecting data, processing data,analyzing systems, and chart - map to assess water quality in the Dong Nai riverbasin based on the analysis of the measured values of 4 parameters as pH, BOD5,COD, DO, compared with QCVN 2015 for river water quality for 5 consecutiveyears from 2011 to 2015 with 12 monitoring points representing upper, middle andlower river. The research results show that the water quality of the Dong Nai riverbasin has a clear differentiation between the monitoring points along the upper,middle and lower of the river. The further lower of the river basin, the pollutionlevel increases. The paper also analyzes the causes of socio-economic developmentand the fluctuation of water quality in the Dong Nai river basin in the context ofpromoting growth.