Đáp ứng miễn dịch của lợn sau khi tiêm vacxin tai xanh nhược độc chủng PRRS HANVET 1.VN

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Ngôn ngữ: Vie

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Thông tin xuất bản: Tạp chí Khoa học kỹ thuật Thú y, 2019

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ID: 395083

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Nghiên cứu đáp ứng miễn dịch của lợn sau khi tiêm vacxin tai xanh nhược độc chủng PRRS Hanvet1.vn đã được tiến hành tại Công ty Hanvet. Sự khác biệt về diễn biến kháng thể trung hòa và kháng thể được xác định bằng phản ứng IPMA trong huyết thanh lợn. Kết quả nghiên cứu cho thấy kháng thể xuất hiện 7 ngày sau miễn dịch và đạt hàm lượng cao nhất vào tuần thứ 5 sau khi tiêm vacxin (1/4888,7), sau đó hàm lượng kháng thể giảm dần, đến tháng thứ 6 chỉ còn 1/463,13. Kháng thể trung hòa xuất hiện muộn, 4 tuần sau khi tiêm vacxin, và đạt hiệu giá cao nhất ở tuần thứ 11 sau miễn dịch (1/21,11) sau đó giảm dần. Đến tháng thứ 5 sau tiêm vacxin, hàm lượng kháng thể trung hòa chỉ còn ¼, đến tháng thứ 6 kháng thể trung hòa không còn khả năng bảo hộ cho lợn. Lợn con sinh ra từ lợn nái đã được tiêm vacxin tai xanh nhận được nhiều kháng thể từ mẹ qua sữa đầu. Hàm lượng kháng thể trong máu lợn con đạt cao nhất vào thời điểm 1 ngày sau sinh (1/1835,46 với IPMA và 1/8,46 với kháng thể trung hòa). Sau đó kháng thể trong máu lợn con giảm nhanh. Đến 14 ngày sau sinh hàm lượng kháng thể trong máu lợn con chỉ còn 1/676,49 (IPMA) và 1/4,11(trung hòa). Lợn 4 tuần tuổi cho đáp ứng miễn dịch tốt nhất sau khi tiêm vacxin., Tóm tắt tiếng anh, The research on immune response of the pigs after vaccination with Hanvet1.vn PRRS attenuated virus vaccine was carried out at Hanvet company. The changes of neutralising antibody and antibody were determined by the IPMA method. The studied result showed that 7 days after vaccination, antibody appeared and reached the highest content in the 5th week after vaccination (1/4888.7), then the antibody content decreased in the 6th month, remaining 1/463.13 only. Neutralising antibody appeared later, 4 weeks after the vaccination, and reached the highest titre at the 11th week after vaccination (1/21.11) then it was decreased. Up to the 5th month after vaccination, the neutralising antibody content remained only ¼ and then the antibody content was not capable to protect the pigs in the 6th month after vaccination. The piglets were born from the sows vaccinated with Hanvet1.vn PRRS vaccine, they received antibody through colostrum. The antibody content in the blood of the piglets reached the highest level at the 1st day after birth (1/1835,46 with IPMA and 1/8.46 with neutralising antibodies). Then antibody content in the blood of piglets decreased rapidly. Up to the 14th days after birth, antibody content in the blood of piglets reached 1/676.49 (IPMA) and 1/4.11 (neutralising). The piglets at 4-weeks-old presented the best immune response after the vaccination.

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