Thực trạng sử dụng thuốc điều trị gút trên bệnh nhân nội trú

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Tác giả: Đặng Minh Trí Bùi, Quang Phúc Đặng, Văn Mãi Đỗ, Đức Thái Hoàng

Ngôn ngữ: Vie

Ký hiệu phân loại: 616.7 *Diseases of musculoskeletal system

Thông tin xuất bản: Y học cộng đồng 2021

Mô tả vật lý: 45580

Bộ sưu tập: Metadata

ID: 397035

Thêm vào giỏ Liên kết toàn văn

Mô tả thực trạng sử dụng thuốc điều trị gút trên bệnh nhân nội trú tại Bệnh viện đa khoa thành phố Cần Thơ. Đối tượng và phương pháp nghiên cứu: Nghiên cứu hồi cứu, cắt ngang, mô tả, không can thiệp dựa trên bệnh án nội trú điều trị Gút tại Bệnh viện đa khoa thành phố Cần Thơ có thời gian vào viện từ 06/2019 - 12/2019. Kết quả: Đa số các bệnh nhân được chỉ định colchicin, chiếm tỷ lệ 91,35%, tiếp theo là meloxicam dùng theo đường uống và đường tiêm, với tỷ lệ lần lượt là 55,77,0% và 29,81%. Bệnh nhân nội trú được dùng phác đồ đơn độc chủ yếu dùng thuốc paracetamol (chiếm 36,11%) và colchicin (chiếm 22,22%). Phác đồ 2 thuốc trên bệnh nhân nội trú được sử dụng nhiều nhất bao gồm: colchicin + paracetamol uống (30,43%), meloxicam uống + paracatamol uống (19,57%). Phác đồ phối hợp 3 thuốc trên nhóm bệnh nhân nội trú bao gồm: colchicin + meloxicam tiêm + paracetamol uống (chiếm tỷ lệ 61,11%). Phác đồ phối hợp 4 thuốc là colchicin + meloxicam tiêm + methylprednisolon uống + paracetamol truyền. Phần lớn bệnh nhân nội trú được thay đổi phác đồ do triệu chứng lâm sàng được cải thiện (chiếm 64,13%). Khoảng 25,54% bệnh nhân cần thay đổi do triệu chứng lâm sàng diễn tiến nặng hơn. Chỉ có 6 bệnh án xuất hiện biến cố bất lợi trong quá trình điều trị, chiếm tỷ lệ 5,77%. Trong đó, rối loạn tiêu hóa chiếm tỷ lệ cao nhất với 50,0%. Kết luận: Bệnh nhân gút điều trị nội trú chủ yếu được chỉ định sử dụng colchicin, meloxicam. Các phác đồ chủ yếu được sử dụng trong đơn trị liệu là paracetamol và colchicin, phác đồ đa trị chủ yếu sử dụng các thuốc colchicin, meloxicam và paracetamol. Tác dụng phụ của thuốc có tỷ lệ thấp với 5,77%., Tóm tắt tiếng anh, To describe the current situation of using drugs to treat gout on inpatients at Can Tho City General Hospital. Subjects and methods: Retrospective, cross-sectional, descriptive, non-intervention study based on inpatient medical records for gout treatment at Can Tho City General Hospital with admission time from June 2019 to December 2019. Results: The majority of patients were prescribed colchicine, accounting for 91.35%, followed by oral and injected meloxicam, with 55.77.0% and 29.81% respectively. Inpatients using a single regimen mainly used paracetamol (accounting for 36.11%) and colchicine (accounting for 22.22%). The most commonly used 2-drug inpatient regimen included: colchicin + oral paracetamol (30.43%), oral meloxicam + oral paracatamol (19.57%). The 3-drug combination regimen on the inpatient group includes: colchicin + injected meloxicam + oral paracetamol (accounting for 61.11%). The four-drug combination regimen was colchicin + injected meloxicam + oral methylprednisolon + infused paracetamol. The majority of inpatients had the regimen changed due to improved clinical symptoms (accounting for 64.13%). Approximately 25.54% of patients need changes due to more severe clinical symptoms. Only 6 medical records showed adverse events during the treatment process, accounting for 5.77%. In which, digestive disorders accounted for the highest percentage with 50.0%. Conclusion: Gout inpatients were mainly indicated for the use of colchicin and meloxicam. The main regimens used in monotherapy were paracetamol and colchicin, the multitherapy regimen mainly used colchicin, meloxicam and paracetamol. Drug side effects were low at 5.77%.

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