Một số yếu tố tiên lượng Shönlein

Một số yếu tố tiên lượng Shönlein - Henoch thể bụng ở trẻ em

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Tác giả: Thị Bình Nguyễn, Thị Diệu Thúy Nguyễn, Thu Thảo Nguyễn

Ngôn ngữ: Vie

Ký hiệu phân loại: 618.92 Pediatrics

Thông tin xuất bản: Nghiên cứu y học (Đại học Y Hà Nội) 2020

Mô tả vật lý: 44-51

Bộ sưu tập: Metadata

ID: 398005

Thêm vào giỏ Liên kết toàn văn

Henoch - Schönlein purpura (HSP) là bệnh tự miễn với tổn thương viêm các thành mạch máu nhỏ. Trongcác cơ quan tổn thương, tổn thương đường tiêu hóa thường là nguyên nhân làm bệnh nhân HSP nhập viện.Nghiên cứu được tiến hành nhằm đánh giá yếu tố tiên lượng HSP thể bụng. Đây là nghiên cứu mô tả, tiến cứumột loạt ca bệnh. Kết quả nghiên cứu có 131 trẻ HSP đủ tiêu chẩn tham gia nghiên cứu, trong đó có 116 bệnhnhân HSP thể bụng và 15 bệnh nhân HSP không thể bụng. Trẻ khởi phát bệnh sau 6 tuổi có nguy cơ khởi phátHSP thể bụng. Số lượng bạch cầu đa nhân trung tính trên 8,34 G/l có giá trị tiên lượng HSP thể bụng với độnhạy là 72,41% và độ đặc hiệu là 60%. Tỷ số bạch cầu trung tính/lympho (NLR) trên 2,03G/l có giá trị tiên lượngHSP thể bụng với độ nhạy là 75% và độ đặc hiệu 73%. Tỷ số tiểu cầu/lympho (PLR) trên 103,2G/l có giá trị tiênlượng HSP thể bụng với độ nhạy là 74,14% và độ đặc hiệu 73,33%. Như vậy, tuổi khởi phát bệnh và các chỉ sốtrong công thức máu như bạch cầu trung tính, bạch cầu lympho, tiểu cầu có giá trị tiên lượng HSP thể bụng., Tóm tắt tiếng anh, Henoch - Schönlein purpura (HSP) is an autoimmune disease with inflammatory lesions ofsmall blood vessels. The gastrointestinal signs such as abdominal pain, vomitting, nausea areoften the leading causes for hospital admissions. A prospective descriptive study was conductedto evaluate the markers indicating gastrointestinal involvement in children with HSP. Patients withHSP were asked to have a routine blood test. The results showed that 131 children with HSPwere eligible to participate in the study, including 116 children with gastrointestinal signs and 15children without any gastrointestinal signs. The onset of children with HSP over 6 years old wasat risk of gastrointestinal involvement. The number of blood neutrophils greater than 8.34 G/l hasa prognostic value of gastrointestinal involvement with the sensitivity of 72.41% and specificity of60%. The neutrophil / lymphocyte ratio (NLR) more than 2.03G/l was associated with gastrointestinalsigns with the sensitivity of 75% and specificity of 73%. Platelet / lymphocyte ratio (PLR) was higherthan 103.2G/l predicting gastrointestinal involvement with the sensitivity of 74.14% and specificityof 73.33%. In conclusion, the age of onsets and indicators in blood counts such as neutrophils,lymphocytes, platelets have a good prognostic value for gastrointestinal signs in children with HSP.

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