Pharmacokinetic modeling of prenatal vitamin D exposure and the impact on offspring asthma and pulmonary function.

 0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Nicklas Brustad, Bo L Chawes, Henk-Jan Guchelaar, Hooman Mirzakhani, Dirk Jan A R Moes, Iskander L C Shadid, Scott T Weiss

Ngôn ngữ: eng

Ký hiệu phân loại: 372.53 *Modeling and sculpture

Thông tin xuất bản: France : Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 398509

 Gestational 25-hydroxyvitamin D (25[OH]D) is important in fetal lung development and may influence offspring respiratory outcomes, making accurate exposure assessment essential to understand clinical associations. Therefore, we used the combined data from two large RCTs investigating prenatal vitamin D supplementation, which included early and late prenatal 25(OH)D measurements, to refine a population pharmacokinetic model of vitamin D-25(OH)D and estimate individual area under the curve (AUC) Z-scores. The primary outcome was physician-diagnosed offspring asthma/wheezing at ages 3 and 6 years, and lung function, as a secondary outcome, was evaluated by spirometry at the ages 6 and 8 years. In total, 1319 mother-child pairs were included. We found that clearance of 25(OH)D increased with gestational age and bodyweight, and decreased with higher baseline 25(OH)D levels. Prenatal 25(OH)D AUC Z-scores were negatively associated with asthma/wheezing at age 3 years (aOR = 0.75, 95 % CI = 0.64-0.88, p <
  0.001) and 6 years (aOR = 0.83, 95 % CI = 0.72-0.95, p = 0.008). Longitudinal analysis of lung function from age 6-8 years showed that AUC Z-scores were positively associated with percent-predicted FEV
Tạo bộ sưu tập với mã QR

THƯ VIỆN - TRƯỜNG ĐẠI HỌC CÔNG NGHỆ TP.HCM

ĐT: (028) 36225755 | Email: tt.thuvien@hutech.edu.vn

Copyright @2024 THƯ VIỆN HUTECH