Tối ưu hóa quy trình phun sấy hỗn dịch nano curcumin

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Tác giả: Hoàng Tùng Nguyễn, Đình Duy Phạm, Quốc Thanh Trần

Ngôn ngữ: Vie

Ký hiệu phân loại: 615.321 Drugs derived from plants

Thông tin xuất bản: Khoa học và công nghệ Việt Nam , 2022

Mô tả vật lý: 20 - 25

Bộ sưu tập: Metadata

ID: 399551

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Nghiên cứu được thực hiện nhằm tối ưu hóa quy trình phun sấy hỗn dịch chứa nano curcumin. Phương pháp nghiên cứu: thiết kế mô hình I-Optimal bằng phần mềm Design Expert, gồm 22 thực nghiệm với các biến độc lập: nhiệt độ đầu vào (oC), tốc độ bơm (ml/phút) và tỷ lệ giá mang
các biến phụ thuộc được khảo sát như kích thước tiểu phân sau phân tán (nm), chỉ số đa phân tán, thời gian phân tán (giây) và hiệu suất phun sấy. Các thông số của quy trình tối ưu được kiểm chứng bằng thực nghiệm và khảo sát một số chỉ tiêu chất lượng. Đồng thời, các đặc tính của curcumin trong sản phẩm bột phun sấy được nghiên cứu bằng nhiễu xạ tia X, phân tích nhiệt quét vi sai và phân tích phổ hồng ngoại. Kết quả cho thấy, phần mềm Desgin Expert đã chỉ ra các thông số tối ưu của quy trình bao gồm nhiệt độ đầu vào 140oC, tốc độ bơm 5 ml/phút, tỷ lệ giá mang 2:1. Quy trình phun sấy sử dụng các giá trị tối ưu trên cho sản phẩm nano curcumin có các tính chất phù hợp với dự đoán của phần mềm. Sự so sánh phổ nhiễu xạ tia X của curcumin và bột nano curcumin cho thấy curcumin trong bột tồn tại ở dạng vô định hình. Phân tích giản đồ nhiệt vi sai của curcumin và bột nano curcumin cùng phân tích phổ hồng ngoại cho thấy có thể có sự tương tác giữa curcumin, chitosan và lipoid S100. Kết luận: quy trình phun sấy hỗn dịch nano curcumin đã được tối ưu hoá ở quy mô phòng thí nghiệm. Đây là nền tảng cho việc tiến tới sản xuất ở quy mô công nghiệp., Tóm tắt tiếng anh, The aim of this study was to optimise spray drying process parameters of curcumin nanosuspension. Method: an I-Optimal experimental model was designed by Design Expert software including 22 experiments. The independent variables were inlet temperature (oC), pump speed (ml/minute) and weight ratio of curcumin-loaded nanoparticles and carrier and nanoparticle
the dependent variables were particle size after redispersing (nm), polydispersity index, dispersion time (second) and spray drying yield. After the optimal parameters had been verified by experiments, some quality requirements of spray-dried powders were evaluated. Then the physical and chemical properties of curcumin in spray-dried powders were studied by X-ray diffraction (XRD), differential scanning calorimetry (DSC) and fourier-transform infrared spectroscopy (FT-IR). Results: the optimal parameters were established with the inlet temperature of 140oC, the pump speed of 5 ml/minute, the weight ratio of carrier and nanoparticle of 2:1. The obtained results of verification experiments were highly repeatable and were similar to the predicted ones from the software. The comparison of XRD spectra between curcumin crystal and spray-dried powders showed that curcumin in spray-dried powders existed in amorphous form. Furthermore, DSC patterns and FT-IR spectra of curcumin crystal and spray-dried powder demonstrated that there were interactions among curcumin, chitosan and lipoid S100. Conclusion: nano curcumin powders have met the quality requirements of preparation in laboratory-scale. This is a platform for further research later and eventually put into industrial-scale production.

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