Tổng hợp benzenesulfonamide serinol bằng phản ứng Hinsberg

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Tác giả: Đại Phú Huỳnh, Ngọc Tấn Nguyễn, Vũ Việt Linh Nguyễn, Thị Xuân Thảo Trần

Ngôn ngữ: Vie

Ký hiệu phân loại:

Thông tin xuất bản: Khoa học & công nghệ Việt Nam 2022

Mô tả vật lý: 44 - 48

Bộ sưu tập: Metadata

ID: 399941

Thêm vào giỏ Liên kết toàn văn

Nghiên cứu tổng hợp benzenesulfonamide serinol (BSSe) - một monomer sulfonamide mới từ phản ứng Hinsberg giữa nhóm amin bậc 1 của serinol (2-amino-1,3-propanediol) và sulfonyl của benzenesulfonyl chloride (BSC) trong môi trường kiềm (NaOH)
khảo sát ảnh hưởng của môi trường phản ứng đến hiệu suất phản ứng và cấu trúc của BSSe. Kết quả phổ cộng hưởng từ hạt nhân proton (H1 NMR) và hồng ngoại biến đổi Fourier (FTIR) cho thấy, sản phẩm BSSe đã được tổng hợp thành công bởi sự xuất hiện của nhóm chức mới sulfonamide (đặc trưng bởi amin bậc 2). Hiệu suất phản ứng đạt cao nhất là 14,51% ở điều kiện phản ứng 22 giờ, tỷ lệ mol BSC/1,4-dioxane là 1/10, nồng độ dung dịch NaOH là 1 M. Trong phân tử BSSe có nhóm sulfonamide và hai nhóm hydroxyl có thể phản ứng dễ dàng với monomer hoặc polyme khác để tạo thành copolyme. BSSe định hướng tổng hợp copolyme ứng dụng làm hydrogel nhạy pH trong hệ dẫn truyền thuốc., Tóm tắt tiếng anh, This research focused on synthesising benzenesulfon-amide serinol (BSSe), a new sulfonamide monomer, by the Hinsberg reaction between primary amine of serinol and sulfonyl of benzenesulfonyl chloride (BSC) in an al-kaline environment. The effect of the reacted environ-ment on the reaction efficiency and structure of BSSe were investigated. The results of the Proton nuclear magnetic resonance (H1 NMR) spectroscopy and Fourier transform infrared (FTIR) spectroscopy indicated that the BSSe was successfully synthesised through the ap-pearance new peak of sulfonamide, characterised by sec-ondary amines. The highest reaction efficiency of BSSe was 14.51% at a reaction time of 22 hours, the mol ratio of BSC/1.4-dioxane was 1/10, the concentration of NaOH solution was 1 M. The BSSe molecule contained the sul-fonamide group and a couple of hydroxyl groups, which were able to copolymerise easily with other monomers or polymers. BSSe was oriented to synthesise copolymer for pH-sensitive hydrogel in the drug delivery system.

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