Ung thư dạ dày ở người trẻ

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Tác giả: Hữu Hoàng, Thị Hoa Nguyễn, Hùng Cường Phạm

Ngôn ngữ: Vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y Dược học - Trường Đại học Y Dược Huế 2023

Mô tả vật lý: 147-151

Bộ sưu tập: Metadata

ID: 401257

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Tóm tắt
Chủ đề

Phân tích sự khác biệt về các đặc điểm dịch tễ học, lâm sàng và tiên lượng của các bệnh nhân ung thư dạ dày tuổi trẻ tại bệnh viện Ung bướu thành phố Hồ Chí Minh. Bệnh nhân và phương pháp: Hồi cứu hồ sơ 299 trường hợp ung thư dạ dày loại carcinôm tuyến được điều trị tại Khoa Ngoại 2, bệnh viện Ung bướu thành phố Hồ Chí Minh từ 01/2016 đến 12/2017. Kết quả: Tỉ lệ bệnh nhân ung thư dạ dày tuổi trẻ (<
40 tuổi) là 8,7% (KTC 95%: 5,5 - 11,9%). Các bệnh nhân ung thư (UT) dạ dày tuổi trẻ so với các bệnh nhân ở tuổi thường gặp: thường có grad mô học của bướu là grad 3 (77% bướu grad 3 so với 52%, p=0,013), có các đặc điểm lâm sàng khác tương tự, có trung vị thời gian sống còn toàn bộ kém hơn (5 tháng so với 12 tháng, p = 0,044). Giai đoạn bệnh là yếu tố tiên lượng sống còn độc lập các bệnh nhân UT dạ dày tuổi trẻ. Các bệnh nhân UT dạ dày tuổi trẻ giai đoạn IV có thời gian sống còn thấp hơn các bệnh nhân khác 3,6 lần (p=0,019). Kết luận: Các bệnh nhân ung thư dạ dày tuổi trẻ (<
40 tuổi) thường có grad mô học của bướu là grad 3, trung vị thời gian sống còn toàn bộ kém, nhưng các đặc điểm lâm sàng khác tương tự các bệnh nhân ở tuổi thường gặp., Tóm tắt tiếng anh, To analyse differences in clinicopathological features and prognosis between gastric cancer patients less than 40-year-old and older. Patients and Methods: Medical records of 299 cases of gastric carcinoma treated from January, 2016 through December, 2017 in Surgery Department No 2, HCMC Oncology Hospital were studied retrospectively. Results: Gastric cancer patients less than 40-year-old were 8.7% (95% CI: 5.5 - 11.9%). Compared to older patients, gastric cancer patients younger than 40 years: more frequently had grade 3 tumors (77% with grade 3 tumors vs 52%, p=0.013), had no difference in other clinicopathologic features, had an inferior median overall survival (5 vs 12 months, p=0.044). TNM stage was an independent prognostic factor in young patients with gastric cancer. For stage IV disease, young adults had overall survival 3.6 times less than older patients (p=0.019). Conclusion: Patients with young-onset gastric cancer were more likely to have grade 3 tumors. Yet, their other clinicopathological features were comparable to older patients. They had an inferior median overall survival.

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