Using English as the medium of instruction (EMI) is seen as a key approach to globalizing education systems in many countries. Its widespread adoption has led to both benefits and drawbacks for students. This study aims to investigate the positive and negative impacts of English-Medium Instruction (EMI) programs at a university in Northeast Vietnam, as perceived by students. The research involved 137 participants enrolled in a language-focused program at a Vietnamese university. Data collection utilized a mixed-methods approach, combining a questionnaire with follow-up interviews. Analysis of the data revealed that EMI courses had a beneficial effect on learners, improving their job prospects, English proficiency, and social skills. However, the findings also highlighted various challenges faced by EMI students, including difficulties with teaching and learning methods, as well as psychological issues during their learning journey. Several suggestions for enhancing the effectiveness of English as a Medium of Instruction (EMI) programs in the Vietnamese educational context are proposed, particularly focusing on teaching and learning strategies.