DOI: https://doi.org/10.59070/jhs010323022 Objective: Determine plasma NT-ProBNP concentrations during the adolescent period. Object and methods of the study: a prospective, cross-sectional study on 112 patients from 10-18 years old examined at the Department of Adolescent Health, Vietnam National Children's Hospital. Quantify plasma NT-ProBNP concentration and compare this index across juvenile stages, gender, and body mass index. Results: NT-ProBNP concentration in females was higher than in males with a statistically significant difference (p<
0.05). There was no statistically significant difference in NT-ProBNP concentrations between the early, middle, and late adolescence stages (p>
0.05). In girls, NT-ProBNP concentrations were higher during puberty than during pre-pubertal periods (p<
0.05), whereas in boys, NT-ProBNP concentrations during puberty were lower than during pre-pubertal (p<
0.05). NT-ProBNP concentration was highest in the underweight group, followed by the normal and overweight groups, and lowest in the obese group with a statistically significant difference (p<
0.05). Conclusion: There are differences in NT-ProBNP concentrations according to gender and no changes were observed in the adolescence stages. NT-ProBNP concentrations varied during puberty and according to body mass index (p<
0.05).