Objective: Research the value of plasma NT-ProBNP concentration in diagnosing congenital heart disease in children. Objects and methods of study: Controlled study on 80 children with congenital heart disease at the Vietnam National Children's Hospital from April 2018 to August 2019. Results: NT-ProBNP concentrations in all types of congenital heart disease were higher than in the control group (p<
0.05). NT-ProBNP concentration was highest in the left-right shunt group and lowest in the cyanotic congenital heart disease group with a statistically significant difference (p>
0.05). NT-ProBNP concentration was highest in the severe heart failure group, followed by the moderate, mild and no heart failure groups and were all higher than the control group (p <
0.01). NT-ProBNP concentration was the highest in the severe pulmonary hypertension group, followed by the moderate, mild, and no pulmonary hypertension groups and were all higher than the control group (p<
0.05). The optimal cutoff point of NT-ProBNP is 671 pg/ml, which is valuable for diagnosing congenital heart disease with a sensitivity of 90.2%, a specificity of 53.1% and an area under the curve of 0.735. Conclusion: NT-ProBNP levels are increased in congenital heart disease in children. Increased NT-ProBNP concentrations are associated with left-right shunting, degree of heart failure and pulmonary hypertension.