Các yếu tố nguy cơ chuyển hóa tim trong dự báo thiếu vitamin D

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Tác giả: Thị Dừa Đào, Thị Nhạn Nguyễn, Trọng Nghĩa Nguyễn, Trung Hiếu Phạm

Ngôn ngữ: Vie

Ký hiệu phân loại: 612.1 Blood and circulation

Thông tin xuất bản: Tạp chí Nội tiết và Đái tháo đường 2021

Mô tả vật lý: 106-111

Bộ sưu tập: Metadata

ID: 403538

Thêm vào giỏ Liên kết toàn văn

Vitamin D là một loại vitamin hòa tan trong chất béo chủ yếu được biết đến với vai trò trong chuyển hóa calci và tích cực tham gia vào một số con đường chuyển hóa, đặc biệt là trong hệ thống tim mạch và kháng insulin. Ước tính hiện tại có 30-50% dân số trên toàn thế giới bị thiếu hụt vitamin D. Mối liên quan giữa các yếu tố nguy cơ chuyển hóa tim với thiếu vitamin D cũng được chứng minh bởi các nghiên cứu. Tuy nhiên, kết quả của một số nghiên cứu khác còn mâu thuẫn và tranh luận. Mục tiêu: (1). Xác định tỷ lệ thiếu vitamin D ở đối tượng nghiên cứu. (2). Khảo sát mối liên quan giữa các yếu tố nguy cơ chuyển hóa tim trong dự báo thiếu vitamin D. Đối tượng và phương pháp nghiên cứu: Sử dụng phương pháp nghiên cứu mô tả cắt ngang ở 320 đối tượng người trưởng thành đến khám sức khỏe tại Trung tâm điều trị theo yêu cầu và quốc tế - Bệnh viện Trung ương Huế. Nồng độ 25-hydroxyvitamin D được đo bằng phương pháp xét nghiệm miễn dịch vi hạt hóa phát quang. Kết quả: Ở đối tượng nghiên cứu, có 182 đối tượng thiếu vitamin D chiếm tỷ lệ 55,2%. Yếu tố tăng vòng bụng, huyết áp tâm thu >
130 mmHg và HOMA-IR >
3,0 là các yếu tố nguy cơ độc lập đối với thiếu vitamin D (OR: 2,91
2,76
3,19
p <
0,05 đến p <
0,001). Kết luận: Tỷ lệ thiếu vitamin D là tỷ lệ 55,2%. Yếu tố tăng vòng bụng, HATT >
130 mmHg và HOMA-IR >
3,0 là các yếu tố nguy cơ độc lập đối với thiếu vitamin D (OR: 2,91
2,76
3,19
p <
0,05 đến p <
0,001), Tóm tắt tiếng anh, Vitamin D is a fat-soluble vitamin mostly known for its role in calcium metabolism. However, it is also actively involved in several metabolic pathways, especially in the cardiovascular system and insulin resistance. Despite vitamin D crucial role, it is estimated that 30-50% of the worldwide population has vitamin D deficiency. A lot of research has investigated the relationships between cardiometabolic risk factors with insufficient vitamin D. However, the results of other studies are conflicting and controversial. Objectives: (1). Determine the prevalence of vitamin D insufficiency in study subjects. (2). Investigate the relationships between cardiometabolic risk factors for predicting insufficient vitamin D. Methods: A cross-sectional study on 320 adult subjects for health examinations at International Medical Center at Hue Central Hospital. Plasma hydroxyvitamin D concentration was measured using chemiluminescent microparticle immunoassay. Results: In study subjects, the prevalence of vitamin D insufficiency was 55,2% (182 participants). Raised waist circumference, SBP >
130 mmHg, and HOMA-IR >
3,0 are independent risk factors for the prediction of vitamin D insufficiency (OR: 2,91
2,76
3,19
p <
0,05 to p <
0,001). Conclusion: The prevalence of vitamin D insufficiency was 55,2% (182 participants). Raised waist circumference, SBP >
130 mmHg, and HOMA-IR >
3,0 are independent risk factors for the prediction of vitamin D insufficiency (OR: 2,91
2,76
3,19
p <
0,05 to p <
0,001).

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