TỶ LỆ NHIỄM RICKETTSIA SPP. Ở NGƯỜI TẠI THÀNH PHỐ BUÔN MA THUỘT, TỈNH ĐẮK LẮK

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Tác giả: Thị Minh Trang Hoàng, Văn Phương Ngô, Ngọc Đỉnh Nguyễn

Ngôn ngữ: Vie

Ký hiệu phân loại: 616.5 Diseases of integument

Thông tin xuất bản: Y Dược học Cần Thơ 2021

Mô tả vật lý: 178-193

Bộ sưu tập: Metadata

ID: 403742

Thêm vào giỏ Liên kết toàn văn

Rickettsia là nhóm vi khuẩn gây bệnh ngẫu nhiên trên người đang được quan tâm trong những năm gần đây. Các bệnh do Rickettsia spp. dễ có nguy cơ bùng phát trong cộng đồng do người nhiễm Rickettsia thường không có triệu chứng lâm sàng điển hình nên dễ bị bỏ qua hay chẩn đoán nhầm. Tại Việt Nam, các nghiên cứu về Rickettsia spp. rất ít nên thông tin về Rickettsia spp. còn rất hạn chế. Mục tiêu nghiên cứu: Xác định tỷ lệ nhiễm Rickettsia spp. ở cộng đồng dân cư tại thành phố Buôn Ma Thuột, tỉnh Đắk Lắk, năm 2020 bằng phương pháp PCR khuếch đại một phần đoạn gene ompB. Đối tượng và phương pháp nghiên cứu: Nghiên cứu cắt ngang trên 156 người từ 10 tuổi trở lên,sử dụng phương pháp PCR xác định sự hiện diện của vi khuẩn Rickettsia spp. trong mẫu máu bằng cách khuyếch đại một phần đoạn gene ompB. Kết quả: Qua xét nghiệm PCR mẫu máu của 156 người tham gia cho thấy tỷ lệ nhiễm Rickettsia spp. tại địa điểm nghiên cứu là 29,5% (Khoảng tin cậy 95%: 22,3% - 36,6%). Các yếu tố gồm giới tính, tuổi, nghề nghiệp và trình độ học vấn không có sự liên quan với tỷ lệ nhiễm Rickettsia spp. trên người. Kết luận: Tỷ lệ nhiễm Rickettsia spp. tại thành phố Buôn Ma Thuột là cao. Cần tiến hành thêm các nghiên cứu với quy mô rộng hơn trên người và vật chủ trung gian để xác định tỷ lệ lưu hành, thành phần loài Rickettsia và các yếu tố nguy cơ của nhiễm Rickettsia spp.., Tóm tắt tiếng anh, Rickettsia is a group of bacteria that causes emerging diseases in humans in recent years. Rickettsial diseases would be widespread in communities as infected people often have no typical clinical symptoms as the result of unnoticed or misdiagnosed. In Vietnam, information about Rickettsia spp. is scarce and the prevalence of Rickettsia spp. infection in the community is unknown. Objectives: To identify the prevalence of Rickettsia spp. infection in humans in Buon Ma Thuot City, Dak Lak Province, in 2020, by PCR method amplifies a spatial gene of the ompB gene. Materials and methods: A cross-sectional study was conducted on 156 people over 10 years old. PCR assays targeting a spatial gene of the ompB gene was used to determine the presence of Rickettsia spp. in human blood samples. Results: A total of 156 human blood samples tested by PCR assay showed that the prevalence of Rickettsia spp. infection in humans at study site was 29.5% (95% confidence interval: 22.3% - 36.6%). These factors such as gender, age, occupation, and education level were not associated with the prevalence of Rickettsia spp. infection in humans. Conclusion: The prevalence of Rickettsia spp. in humans at Buon Ma Thuot City was high. Further studies on humans and intermediate hosts are needed to determine the true prevalence, identification of Rickettsia species and risk factors of Rickettsia spp. infection.

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