Ứng dụng của biến thiên sinh học trong thực hành lâm sàng

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Tác giả: Thị Chi Mai Trần

Ngôn ngữ: Vie

Ký hiệu phân loại: 610 Medicine and health

Thông tin xuất bản: Journal of Pediatric Research and Practice, 2022

Mô tả vật lý: 45297

Bộ sưu tập: Metadata

ID: 404115

Thêm vào giỏ Liên kết toàn văn

Biến thiên sinh học bao gồm biến thiên cá thể (Intra-individual coefficient of variation) và biến thiên quần thể (Inter-individual coefficient of variation). Biến thiên sinh học có nhiều ứng dụng trong thực hành y khoa. Khái niệm giá trị thay đổi tham chiếu (RCV) dựa trên biến thiên phân tích và biến thiên cá thể được đưa ra nhằm xác định xem sự khác biệt giữa các kết quả liên tiếp của một chất phân tích trên một bệnh nhân có thể có ý nghĩa lâm sàng hay không. Đây là một cách tiếp cận khoa học hơn cho việc đánh giá những thay đổi có ý nghĩa lâm sàng giữa các kết quả xét nghiệm liên tiếp mà trước đây các bác sĩ chủ yếu dựa vào trực giác và kinh nghiệm. Chỉ số cá thể (Index of Individuality) cho phép so sánh sự biến thiên sinh học cá thể và sự biến thiên sinh học quần thể. Khi chỉ số cá thể ở mức thấp (<
0,6), các giá trị cho bất kỳ cá thể nào chỉ là một phần nhỏ của khoảng tham chiếu. Các giá trị tham chiếu sẽ không có ích, đặc biệt là khi quyết định xem các thay đổi trong một cá thể có xảy ra hay không. Ngược lại, khi II cao (>
1,4), các giá trị từ một cá thể sẽ bao gồm phần lớn phân phối của khoảng tham chiếu. Do đó, các giá trị tham chiếu sẽ có giá trị đáng kể trong nhiều tình huống lâm sàng., Tóm tắt tiếng anh, Categories of biological variation include intraindividual variation and interindividual variation. Biological variability is not only fundamental in the interpretation of test results, but also influences clinical decisions. The concept of reference change value (RCV) based on analytical and individual variations are developed to determine whether a difference between consecutive results of one analyte in a patient might have clinical significance. The concept introduces a scientific approach to an area where clinicians have largely relied on their intuition and experience. Index of individuality (II) allows a comparison of intraindividual biological variation to interindividual variation. When II is low (<
0.6), values for any individual span only a small part of the reference interval. Reference values will be of little utility, particularly when deciding whether changes in an individual have occurred. In contrast, when II is high (>
1.4), values from an individual will cover much of distribution of the reference interval. Thus, conventional reference values will be of significant value in many clinical settings.

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