Độc tính bán cấp qua đường miệng của viên nang cứng Hamo NK trên động vật thực nghiệm

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Tác giả: Quốc Bình Phạm, Thủy Phuong Phạm, Vũ Lâm Trịnh

Ngôn ngữ: Vie

Ký hiệu phân loại: 615.9 Toxicology

Thông tin xuất bản: Y dược Cổ truyền Việt Nam 2023

Mô tả vật lý: 45391

Bộ sưu tập: Metadata

ID: 406510

Thêm vào giỏ Liên kết toàn văn

Viên nang cứng Hamo N K bao gồm một số công thức chiết xuất khô của dược thảo đã cho thấy đặc tính tốt trong điều trị rối loạn mỡ máu hiệu quả. Tuy nhiên, không có báo cáo khoa học nào về các đặc tính độc tính của nó đảm bảo tính an toàn khi sử dụng nó như một loại thuốc điều trị rối loạn lipid máu hiệu quả. Do đó, nghiên cứu hiện tại là điều tra độc tính bán cấp tính của Hamo N K trên chuột thông qua đường uống. Phương pháp M: Homo N K dùng bán cấp đã được nghiên cứu trên chuột Wistar. Các con vật được tiếp xúc bằng miệng với 0,25 g/kg và 0,75 g/kg thể trọng/ngày của Hatno N K trong 12 tuần liên tiếp. Quan sát vật lý và trọng lượng cơ thể đã được thực hiện trong thời gian nghiên cứu. Vào cuối thí nghiệm, các mẫu máu được thu thập để đánh giá huyết học và hóa học lâm sàng. Bệnh lý đại thể và mô bệnh học của gan và thận đã được đánh giá. Kết quả: Không quan sát thấy sự thay đổi lớn nào trong các thông số được đánh giá ở hai liều 0,25 g/kg mỗi ngày và 0,75 g/kg mỗi ngày. Phân tích mô bệnh học của gan và thận cho thấy cấu trúc bình thường. Kết luận: Nói chung, những dữ liệu này chứng minh rằng viên nang cứng Hamo N K có biên độ an toàn cao., Tóm tắt tiếng anh, Hamo N K hard capsule is composed of some dry extracts formulation of herbal medicine which had shown good properties effective treating dyslipidemia. However, there are no scientific reports of its toxicological properties which guarantee of the safety its usage as a potent treating dyslipidemia. Therefore, the present study was to investigate sub-acute toxicity ofHamo N K on rats through oral administration. M ethods: The sub-acute administration Homo N K was studied on Wistar rats. The animals were orally exposed to 0.25g/kg and 0.75 g/kg b.w/day ofHatno N K for 12 consecutive weeks. Physical observations and body weight were made during the study period. A t the end of the experiment, blood samples were collected for hematology and clinical chemistry evaluations. Gross pathology and histopathology of livers and kidneys were assessed. Result: No major alteration was observed in the evaluated parameters at two doses of 0.25 g/kgper day and 0.75 g/kgper day. The histopathologic analysis of the livers and kidneys indicated architecture with normal aspect. Conclusion: Collectively, these data demonstrate that Hamo N K hard capsule has a high margin of safety.

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