Bệnh da bóng nước thai kỳ - Pemphygoid gestationis: nhân một trường hợp và hồi cứu y văn

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Tác giả: Kim Quang Huỳnh, Minh Nhật Huỳnh, Hà Yến Chi Lê, Chí Kông Phạm

Ngôn ngữ: Vie

Ký hiệu phân loại: 618 Other branches of medicine Gynecology and obstetrics

Thông tin xuất bản: Tạp chí Phụ sản 2023

Mô tả vật lý: 116-121

Bộ sưu tập: Metadata

ID: 406772

Thêm vào giỏ Liên kết toàn văn

Bệnh da bóng nước tự miễn là một nhóm bệnh bóng nước có triệu chứng đa dạng, cơ chế bệnh sinh đặc trưng bởi sự xuất hiện các tự kháng thể chống lại các protein tham gia liên kết tế bào da dẫn đến hình thành các sang thương bóng nước trên lâm sàng. Mặc dù tỷ lệ hiện mắc bệnh bóng nước trong thai kỳ là hiếm (tỷ lệ mắc bệnh là 1 trên 20.000 đến 50.000 phụ nữ mang thai), nhưng chủ đề này đáng được quan tâm do làm thay đổi quy trình theo dõi thai nghén, gây khó khăn trong việc kiểm soát triệu chứng (ngứa, tổn thương da) cũng như ảnh hưởng tiên lượng sơ sinh. Chẩn đoán phân biệt các tổn thương da bóng nước trong thai kỳ là một thách thức do các triệu chứng lâm sàng thường thay đổi và thiếu các xét nghiệm chẩn đoán xác định. Lựa chọn và sử dụng các thuốc ức chế miễn dịch để điều trị và kiểm soát bệnh cũng cần được cân nhắc cẩn thận. Chúng tôi trình bày một trường hợp bệnh da bóng nước miễn dịch xuất hiện trong thời kỳ mang thai - Pemphygoid Gestationis - thuộc nhóm bệnh da đặc hiệu thai kỳ (Specific Dermatosis of Pregnancy), trong đó phân biệt bệnh chủ yếu dựa trên biểu hiện lâm sàng, chẩn đoán, điều trị, yếu tố nguy cơ kèm theo và tiên lượng., Tóm tắt tiếng anh, Autoimmune bullous skin disease is a group of blistering diseases with diverse symptoms, the pathogenesis is characterized by the appearance of autoantibodies against proteins involved in skin cell binding leading to the formation of "blisters". Although the prevalence of bullous disease in pregnancy is rare (incidence is 1 in 20,000 to 50,000 pregnant women), the topic "needs to pay" attention because of the changing protocols of pregnancy monitoring, "causing" difficulty in "symptoms" control (pruritus, skin lesions) as well as "affecting" neonatal prognosis. Differential diagnosis of bullous skin lesions in pregnancy is "still" "challenged" "due to" the "variation" clinical presentation and the lack of definitive diagnostic tests. The selection and use of immunosuppressive agents to treat and control the disease should also be carefully considered. We present a case of immunogenic bullous skin disease occurring during pregnancy - Pemphygoid Gestationis - "classificated on" Specific Dermatosis of Pregnancy, in which the disease distinction is mainly based on clinical, diagnosis, treatment as well risk factors and prognosis.

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