Nghiên cứu một số chỉ số xét nghiệm của bệnh nhân đa u tuỷ xương chuỗi nhẹ tại bệnh viện bạch mai

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Tác giả: Thị Phương Oanh Ngô

Ngôn ngữ: Vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y học Việt Nam 2023

Mô tả vật lý: 146-150

Bộ sưu tập: Metadata

ID: 408474

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Tóm tắt
Chủ đề

Đa u tuỷ xương chuỗi nhẹ (LCMM) chiếm khoảng 15-20% bệnh nhân đa u tuỷ, có tiên lượng xấu, đáp ứng điều trị kém hơn so với các nhóm khác, khó phát hiện sớm ở các bệnh viện không phải tuyến chuyên khoa, bệnh nhân thường được chẩn đoán bệnh muộn có nhiều biến chứng (thiếu máu, suy thận, loãng xương). Để chẩn đoán sớm và kịp thời, các nghiên cứu về đặc điểm các xét nghiệm cơ bản thường gặp của bệnh nhân mắc LCMM là vô cùng cần thiết. Mục tiêu: nghiên cứu một số chỉ số xét nghiệm của bệnh nhân LCMM đến khám và điều trị tại Bệnh viện Bạch Mai. Đối tượng, phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên 50 bệnh nhân mới chẩn đoán LCMM từ 01/2018 đến 07/2022, điều trị tại Bệnh viện Bạch Mai. Kết quả: Bệnh nhân LCMM có biểu hiện tăng protein máu, giảm albumin máu, và chỉ số A/G đảo ngược tỷ lệ thấp, lần lượt là 2%, 8% và 16%. Tỷ lệ bệnh nhân tăng beta-2-microglobulin chiếm 82%. Tỷ lệ bệnh nhân có chỉ số LDH bình thường chiếm 96%. Tỷ lệ bệnh nhân có chỉ số Calci toàn phần bình thường chiếm 82%. Kết luận: Các xét nghiệm của bệnh nhân LCMM có biểu hiện tăng protein máu và beta-2-microglobulin, giảm albumin máu, chỉ số A/G đảo ngược tỷ lệ thấp, LDH và Calci toàn phần bình thường., Tóm tắt tiếng anh, Light chain multiple myeloma (LCMM) accounts for about 15-20% of patients with multiple myeloma, has a poor prognosis, has a poorer response to treatment than other groups, and is difficult to detect early in hospitals, patients are often diagnosed late with many complications (anemia, kidney failure, osteoporosis). For early and timely diagnosis, studies on the characteristics of common basic tests of patients with LCMM are essential. Objectives: Research of some laboratory indicators of LCMM patients who come for examination and treatment at Bach Mai Hospital. Subjects, research methods: A cross-sectional descriptive study on 50 patients newly diagnosed with LCMM from 01/2018 to 07/2022, treated at Bach Mai Hospital. Results: Patients with LCMM had low rates of hyperproteinemia, hypoalbuminemia, and A/G inversion, 2%, 8%, and 16%, respectively. The proportion of patients with increased beta-2-microglobulin accounted for 82%. The proportion of patients with normal LDH index accounted for 96%. The proportion of patients with normal total calcium index accounted for 82%. Conclusion: The laboratory indicators of LCMM patients showed hyperproteinemia and beta-2-microglobulin, hypoalbuminemia, low A/G ratio reversed, LDH and total calcium were normal.

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