Các kháng thể kháng tiểu đảo tụy ở trẻ em đái tháo đường mới được chẩn đoán

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Tác giả: Thị Bích Ngọc Cấn, Chí Dũng Vũ

Ngôn ngữ: Vie

Ký hiệu phân loại: 616.4 Diseases of hematopoietic, lymphatic, glandular systems Diseases of endocrine system

Thông tin xuất bản: Nội tiết và Đái tháo đường 2021

Mô tả vật lý: 102-108

Bộ sưu tập: Metadata

ID: 408527

Thêm vào giỏ Liên kết toàn văn

Đánh giá sự thay đổi các kháng thể ICA, GADA, IA- 2A và ZnT8 ở bệnh nhân đái tháo đường mới được chẩn đoán. Đối tượng và phương pháp nghiên cứu: Nghiên cứu một loạt ca bệnh trên 34 bệnh nhân đái tháo đường mới được chẩn đoán. Kết quả: 34 bệnh nhân đái đường, 20 nữ, 14 nam, tuổi chẩn đoán 6,2 ±4,2 tuổi (3 ngày - 14 tuổi). 9/34 bệnh nhân có nhiễm toan xê tôn ở thời điểm chẩn đoán, 5/34 bệnh nhân có béo phì với BMI >
97th. 24 bệnh nhân ĐTĐ không kèm theo béo phì, và 5 bệnh nhân ĐTĐ xuất hiện trước 6 tháng tuổi - ĐTĐ sơ sinh. 5/5 bệnh nhân ĐTĐ có béo phìvà 5/5 bệnh nhân ĐTĐ sơ sinh âm tính với cả 4 loại kháng thể. Trong số 24 bệnh nhân còn lại, tỷ lệ dương tính với ít nhất 2 loại kháng thể là 17/24 ,7/24 dương tính mạnh với cả 4 kháng thể, 3/24 dương tính 3 kháng thể, 7/24 dương tính với 2 kháng thể, 7/24 âm tính với cả 4 kháng thể. Kết luận: Phát hiện các tự kháng thể tiểu đảo tuỵ giúp chẩn đoán các thể đái đường và giúp định hướng kế hoạch điều trị cũng như kiểm soát đái đường., Tóm tắt tiếng anh, Type 1 diabetes is an autoimmune disease resulting from the destruction of the insulinproducing beta cells in the pancreas. There are many autoantibodies in patients with type 1 diabetes. In there, the 4 major autoantibodies are islet-cell cytoplasmic autoantibodies (ICA), glutamid acid decarboxylase antibody (GADA), islet antigen-2 antibody (IA-2A), and insulin autoantibodies (IAA). However, the quantification of IAA is no longer effective because the IAA is the most difficult to accurately measure and reproducible, especially when exogenous insulin is used. Therefore, antibodies to ZnT8 may improve the value of antibodies. Objective: To evaluate the changes in antibodies to ICA, GAD, IA-2, and ZnT8 in newly diagnosed diabetic patients. Method: Case series report on34 patients were first diagnosed from January 2019 to August 2020. Results: 34 patients (20 females and 20 males) were diagnosed at 6,2 ±4,2 years (3 days - 14 years), 9/34 patients had keto acidosis, 5 patients had obesity with BMI >
97th, 5 patients were diagnosed before 6 months of age (NDM). The patients who had obesity and NDM was negative with 4 autoantibodies. In 24 remain patients, 70.1% (17/24) had atleast 2 autoantibodies, 29.1% (7/24) had 4 autoantibodies, 12.5 % (3/24) had 3 autoantibodies, 29.1 % had 2 autoantibodies. Conclusion: Detection of pancreatic autoantibodies helps diagnose diabetes types and helps guide the treatment plan and control of diabetes.

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