Nghiên cứu hiệu quả điều trị iode phóng xạ (I131) ở bệnh nhân basedow tại Bệnh viện Trung ương Huế

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Tác giả: Thị Dừa Đào, Thừa Nguyên Trần

Ngôn ngữ: Vie

Ký hiệu phân loại:

Thông tin xuất bản: Nội tiết và Đái tháo đường 2021

Mô tả vật lý: 82-88

Bộ sưu tập: Metadata

ID: 411702

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Chủ đề

Khảo sát sự thay đổi hình thái và chức năng tuyến giáp sau 3 tháng và 6 tháng điều trị I131 ở bệnh nhân Basedow. Đối tượng và phương pháp nghiên cứu: Gồm 63 bệnh nhân chẩn đoán bệnh Basedow được chỉ định điều trị bằng I131. Phương pháp nghiên cứu mô tả cắt ngang và tiến cứu: bướu giáp, thể tích tuyến giáp trên siêu âm độ tập trung I131, nồng độ T3, T4, TSH. Kết quả: Sau 3 tháng điều trị Basedow với I131, bướu giáp độ II là 39,29 % và độ III là 7,14 % thể tích thùy phải tuyến giáp là 27,22±15,77(ml) và thùy trái là 25,43±15,18(ml). Sau 6 tháng điều trị Basedow với I131, chỉ còn bướu giáp độ II (7,41 %) thể tích thùy phải tuyến giáp là 16,81±10,92 (ml) và thùy trái là 13,85±83,91 (ml). Về chức năng tuyến giáp: Sau 3 tháng điều trị, tỷ lệ cường giáp giảm còn 41,10 %, bình giáp đạt 35,71 % và suy giáp dưới lâm sàng là 23,21 %. Sau 6 tháng, tỷ lệ cường giáp giảm còn 18,52 %, bình giáp đạt 51,85% và suy giáp dưới lâm sàng là 29,63%. Kết luận: Bướu giáp và thể tích tuyến giáp giảm sau 3 tháng và 6 tháng điều trị I131 ở bệnh nhân Basedow so với trước điều trị có ý nghĩa thống kê. Chức năng giáp cũng cải thiện theo chiều hướng bình giáp., Tóm tắt tiếng anh, Basedow is autoimmune disease causes hyperthyroidism and a lot of severe complications. Objectives: To study figure and function of thyroid gland after 3 months and 6 months treating with I 131 in Basedow patients. Subjects and method: 63 Basedow patients. This was a cross-sectional descriptive and prospective study. Patiens were examined: figure of thyroid gland (goiter, thyroid volume) and function thyroid gland (I 131 concentrate at thyroid gland, concentration T3, T4, TSH, TRAb). Results: After 3 months treatment Basedow with I131, goiter degree II was 39.29% and degree III was 7.14% right lobe thyroid volume was 27,22±15,77(ml) and left lobe was 25,43±15,18(ml). After 6 months treatment Basedow with I131, goiter degree II was 7.14% right lobe thyroid volume was 16,81±10,92 (ml) and left lobe was 13,85±83,91 (ml)). After 3 months treatment, rate hyperthyrodisum was 41.10 %, euthyroidism was 35.52 % and hypothyroidism 23.21 %. After 6 months treatment, rate hyperthyrodisum was 18.10 %, euthyroidism was 51.85% and hypothyroidism 29.63 %. Conclusion: Goiter and thyroid volume were smaller after 3 months and 6 month treatment with I131 in Basedow patients than befor treatment statistical significance. function of thyroid gland after 3 months and 6 months treating with I131 improving trend euthyroidism.

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