Nghiên cứu đặc điểm lâm sàng, mô bệnh học u Lympho ác tính không Hodgkin vùng đồ cổ

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Tác giả: Thanh Bình Nguyễn, Xuân Thắng Tống

Ngôn ngữ: Vie

Ký hiệu phân loại: 611 Human anatomy, cytology, histology

Thông tin xuất bản: Tạp chí khoa học và công nghệ Việt Nam, 2020

Mô tả vật lý: 13 - 16

Bộ sưu tập: Metadata

ID: 413596

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Tóm tắt
Chủ đề

Mục tiêu của đề tài là nghiên cứu một số đặc điểm lâm sàng, cận lâm sàng bệnh u lympho ác tính không Hodgkin (ULAKH) vùng đầu cô. Phương pháp nghiên cứu mô tã hồi cứu kết hợp tiến cứu trên 98 bệnh nhân ULAKH vùng đầu cô điều trị bằng phác đồ R-CHOP được chẩn đoán và điều trị tại Bệnh viện Tai Mũi Họng Trung ương và Bệnh viện K
nhận xét về các triệu chứng cơ năng, thực thể, toàn thân, xét nghiệm huyết học, mô bệnh học và hóa mô miễn dịch. Kết quả nghiên cứu cho thấy, nhóm tuổi gặp chủ yếu là 51-60. Tỷ lệ bệnh nhân nam/nữ là 1/1,09. Thời gian khởi bệnh đến khi được chấn doán chủ yếu <
3 tháng. Vị trí hay gặp nhất
amidan 42,9%, hạch cô 34,7%, vòm 5,1%. Triệu chứng hay gặp là nuốt đau, nuốt vướng và hạch cổ. Vị trí hiếm gặp như ở hốc mắt 3,0%, hốc mũi 6,1% và đáy lưỡi 8,2%. Triệu chứng có hạch to gặp 34,7%. Giai đoạn theo Ann-Arbor chủ yếu là giai đoạn II, chiêm 57,1%. Hội chứng B gặp 15,3% và chủ yếu là giai đoạn II. Mô bệnh học hay gặp nhất là thể B lớn lan tỏa (diffuse large B-cell lymphoma - DLBCL) 70,4%, u lympho thể nang 7,14%, u lympho tế bào áo nang 8,18%. Loại mô bệnh học hay gặp nhất là WF6 và WF7. Qua nghiên cứu có thể kết luận ULAKH vùng đầu cổ hay gặp nhất là ở vòng Waldeyer và amidan với triệu chứng biểu hiện tại chỗ là chủ yếu, giai đoạn II, mô bệnh học chủ yếu là DLBCL., Tóm tắt tiếng anh, Aims to assess clinical features and histopathologic type of non-Hodgkin lymphoma in head and neck. Methods retrospective and prospective studies on 98 patients with non-Hodgkin lymphoma in head and neck treatment with RCHOP. The study focused on describing the clinical and paraclinical symptoms of non-Hodgkin lymphoma. Results the group of age mostly acquired was 51-60 y.o. The proportion of male and female patients was 1/1.09. The time from symptoms begin to diagnose was mainly under 3 months. The most common non- Hodgkin lymphomas were located in tonsils 42.9%, neck node 34.7%, and arches 5.1% with symptoms such as otalgia, dysphagia, and neck node enlargement. Very rare lymphoma was found at eye socket 3.0%, nasal cavity 6.1%, and tongue base 8.2%. Cases with lymphadenopathy were estimated at 34.7%. Ann- Arbor stage II accounted for the largest part of 57.1%. Syndrome B was mainly stage II with 15.3%. In this research, the most common histopathology was diffuse large B-cell lymphoma (DLBCL) 70.4%, followed by mantle cell 8.18% and follicular lymphoma 7.14%. WF6 and WF7 were the most common histopathologic types. Conclusion non-Hodgkin lymphoma in head and neck was mostly located in the Waldeyer's ring with local symptoms of tumour, neck node enlargement
at the Ann-Arbor stage II, DLBCL was the most common histopathologic type.

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