Khảo sát một số hoạt tính sinh học của loài địa tiễn Marchantia polymorpha L. thu hái tại Đà Lạt, Lâm Đồng

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Tác giả: Thiện Tâm Lương, Ngô Hoang Phan, Ngô Diễm Phương Quách, Quốc Tân Trần

Ngôn ngữ: Vie

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Thông tin xuất bản: Tạp chí Phát triển Khoa học và Công nghệ: Chuyên san Khoa học Tự nhiên, 2018

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Địa tiễn Marchantia polymorpha L. được sử dụng trong y học dân gian Ấn Độ, Trung Quốc... để điều trị viêm loét, các vết thương hở, lợi tiểu... Hiện nay, thế giới đã có những nghiên cứu về các hoạt chất và hoạt tính sinh học của loài địa tiễn này. Trong khi đó, các nghiên cứu về đài thực vật (thực vật không mạch) ở Việt Nam còn khá mới mẻ. Do đó, bài báo tập trung vào các hoạt tính sinh học và khảo sát sự hiện diện của một số nhóm hợp chất thứ cấp của các cao chiết từ loài Marchantia polymorpha L. thu hái tại thành phố Đà Lạt, tỉnh Lâm Đồng. Trong bốn phân đoạn (n-hexane, chloroform, ethyl acetate và ethanol) thì cao chiết chloroform có hoạt tính kháng oxy hóa, kháng khuẩn và ức chế tăng sinh dòng tế bào MCF-7 tốt nhất. Cao chiết ethyl acetate có khả năng ức chế enzyme tyrosinase và α-glucosidase tốt nhất. Các nhóm hợp chất thứ cấp hiện diện chủ yếu là phenolic, steroid và các dẫn xuất glycoside. Kết quả giúp làm rõ được một số ứng dụng trong điều trị của dân gian và những tiềm năng mới của loài địa tiễn này., Tóm tắt tiếng anh, Marchantia polymorpha L. is used as a folk medicine in India, China and some European countries for the treatment of inflammation, cure cuts, wounds, diuretics, etc. Natural compounds and biological activities of this liverwort have been studied in the world for few years. At present time, the studies on bryophytes (non-vascular plants) are quite limited, especially in Vietnam. Therefore, this research focused on investigating some biological activities and analyzing of major secondary metabolites of M. polymorpha L. collected at Da Lat, Lam Dong. Among four extracted fractions (nhexane, chloroform, ethyl acetate and ethanol), the chloroform extract exhibited the best antioxidant, antibacterial, anti-proliferation of MCF-7 cell line activities. The ethyl acetate extract exhibited better activity of tyrosinase and α-glucosidase inhibition than others. Main secondary compounds in this species were phenolics, steroids and glycosidederivatives. These results were scientific evidences that might help us to understand rigorously about the ultilization of Marchantia liverwort in the traditional treatment and new potential applications in the contemporary medicine.

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