NHẬN XÉT ĐẶC ĐIỂM HÌNH ẢNH 18F-FDG PET/CT CỦA U LYMPHO KHÔNG HODGKIN TẾ BÀO B TẠI BỆNH VIỆN UNG BƯỚU HÀ NỘI

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Tác giả: Văn Tuynh Chu, Văn Thắng Nguyễn, Văn Thái Phạm

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Điện quang và Y học hạt nhân Việt Nam, 2024

Mô tả vật lý: tr.40-45

Bộ sưu tập: Báo, Tạp chí

ID: 414902

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Mục tiêu: Nghiên cứu nhằm nhận xét đặc điểm hình ảnh 18F-FDG PET/CT của U lympho không Hodgkin tế bào B tại bệnh viện Ung bướu Hà Nội. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả, hồi cứu 86 bệnh nhân được chẩn đoán u lympho không Hodgkin dựa vào mô bệnh học và hóa mô miễn dịch tại bệnh viện Ung bướu Hà Nội từ 01/2018 đến tháng 12/2022, các bệnh nhân được chụp PET/CT chẩn đoán giai đoạn trước điều trị. Kết quả: 86 bệnh nhân được chọn vào nghiên cứu gồm 38 nữ và 48 nam, tuổi trung bình là 58,1 ± 16,2. 72 bệnh nhân có giải phẫu bệnh thuộc nhóm tiến triển nhanh, trong đó u lympho không Hodgkin tế bào B lớn lan tỏa chiếm 45,3%. Trên PET/CT phát hiện hạch cổ và hạch ổ bụng là hai vị trí hay gặp nhất với tỉ lệ lần lượt là 65,1% và 53,5%, các vị trí hạch khác như hạch trung thất là 34,9%, hạch nách 30,2%, hạch bẹn 22,1%. PET/CT phát hiện 23 vị trí/ cơ quan ngoài hạch, hay gặp nhất là amiđan (16,3%), lách (9,3%), tủy xương (9,3%), dạ dày (8,1%), vòm (7,0%). Giá trị trung vị SUVmax của nhóm tiến triển nhanh là 11,3, nhóm tiến triển chậm là 5,4, p <
0,01. Phân tích tương quan giữa kích thước và giá trị SUVmax của tổn thương cho thấy rs = 0,547, p <
0,01. Kết luận: Chụp PET/CT giúp phát hiện tổn thương ULPKH tế bào B tại nhiều vị trí. Nhóm tiến triển nhanh có SUVmax cao hơn nhóm tiến triển chậm. Nghiên cứu này chỉ ra có mối tương quan thuận giữa kích thước và giá trị SUVmax của tổn thương.Objective: This study aimed to review 18F-FDG PET/CT imaging characteristics of B cell Non-Hodgkin’s lymphoma at Hanoi Oncology Hospital. Materials and Methods: A retrospective descriptive study was conducted on 86 newly diagnosed B cell Non Hodgkin’s lymphoma by histopathology and immunohistochemistry at Hanoi Oncology Hospital from January 2018 to December 2022. Those patients undergone 18F-FDG PET/CT scans for pre-treatment staging. Results: Among 86 B cell NHL patients, 38 female and 48 male with mean age was 58.1 ± 16.2. There were 72 patients with aggressive NHL, in which DLBCL accounted for 45.3%. According to PET/CT imaging, the highest frequency lymph nodes were cervical and abdominal lymph nodes with 65.1% and 53.5%, correspondingly. The other lymph nodes were mediastinal (34.9%), axillary (30.2%) and inguinal (22.1%). PET/CT showed 23 extranodal sites/organs, most commonly were tonsil (16.3%), spleen (9.3%), bone marrow (9.3%), stomach (8.1%), nasopharynx (7.0%). The median SUVmax of aggressive NHL was 11.3, indolent NHL was 5.4, p <
0.01. Analysis of the correlation between size and SUVmax showed rs = 0.547, p<
0.01. Conclusions: PET/CT helps to detect lesions of B cell NHL at many sites. The SUVmax value of aggressive group higher than indolent group. This study show there was a positive correlation between size and SUVmax.

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