Khảo sát hiệu quả điều trị sẹo của gel thông minh nhạy nhiệt chứa liposome đóng gói curcumin

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Tác giả: Minh Hiệp Nguyễn

Ngôn ngữ: Vie

Ký hiệu phân loại: 615 Pharmacology and therapeutics

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ Đại học Thái Nguyên, 2022

Mô tả vật lý: 117-125

Bộ sưu tập: Metadata

ID: 422159

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Nghiên cứu nhằm mục đích đánh giá khả năng điều trị sẹo của gel thông minh nhạy nhiệt chứa liposome đóng gói curcumin (GelTM-Lip-CUR). Đầu tiên, Lip-CUR được tổng hợp bằng phương pháp hydrate hóa màng lipid kết hợp với sóng siêu âm để giảm kích thước. GelTM chứa Lip-CUR được điều chế từ Pluronic F127 và PVA. Hiệu quả điều trị sẹo của Lip-CUR và GelTM-Lip- CUR được thực hiện trên chuột nhắt trắng. Kết quả thực nghiệm cho thấy, Lip-CUR đã được tổng hợp thành công với kích thước hạt, chỉ số phân tán, thế zeta, hiệu suất đóng gói, sức tải lần lượt là 229,6 nm, 0,245, -26,6 mV, 90,2%, 8,1% và có độ bền tương đối cao. GelTM-Lip-CUR có trạng thái lỏng ở nhiệt độ thấp hơn 25oC và trạng thái gel khi tiếp xúc với nhiệt độ cơ thể. Kết quả khảo sát trên chuột nhắt trắng cho thấy, Lip-CUR cho hiệu quả điều trị sẹo tốt hơn rất nhiều so với CUR dạng thô. Hơn nữa, GelTM-Lip-CUR cho hiệu quả điều trị sẹo tốt hơn Lip-CUR và đạt hiệu quả điều trị tốt nhất ở nồng độ CUR 0,05 mg/mL. Kết quả phân tích mô học cho thấy cấu trúc mô da vùng sẹo của nghiệm thức GelTM-Lip-CUR ở nồng độ CUR 0,05 mg/mL đã hồi phục gần như hoàn toàn
từ đó cho thấy tiềm năng ứng dụng thực tiễn to lớn của GelTM-Lip-CUR trong lĩnh vực điều trị sẹo., Tóm tắt tiếng anh, This study aims to evaluate scar treatment effectiveness of thermal-responsive gel containing curcumin-encapsulated liposome (GelTM-Lip-CUR). Firstly, Lip-CUR was prepared using a combined method of lipid-film hydration and sonication. GelTM-Lip-CUR was prepared from F127 and PVA. Scar treatment effectiveness of Lip-CUR and Gel-Lip-CUR was carried out using mice Mus. musculus var. Albino. The results indicated that Lip-CUR was successfully prepared with mean particle size, polydispersity index, zeta potential, encapsulation efficieny, payload of 229.6 nm, 0.245, -26.6 mV, 90.2%, 8.1%, respectively. In addition, the results also showed that Lip-CUR was stable under storage conditions. GelTM-Lip-CUR was liquid at a temperature of lower than 25oC and gelled at body temperature. The in vivo results on mice Mus. musculus var. Albino indicated that, scar treatment efficiency of Lip-CUR was higher than that of native CUR, and achieved the highest efficiency at CUR concentration of 0.01 mg/mL. Moreover, GelTM- Lip-CUR exhibited a significant better scar treatment effect compared to Lip- CUR, with the optimal CUR concentration of 0.05 mg/mL. The results of histological analysis indicated that the tissue structure at the scar area of GelTM-Lip-CUR at a CUR concentration of 0.05 mg/mL was nearly fully recovered to normal. Therefore, GelTM-Lip-CUR has a great potential to be widely applied in scar treatment.

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