The article deals with the issues of meteorological drought in the coastal area of the estuary of the Tien river, including Tien Giang and Ben Tre provinces, which have favorable climatic conditions for agricultural development. In the context of climate change, drought often happens, seriously affecting the local economy. In order to estimate the drought level, scientists have come up with many approaches to calculate drought indices for different regions and territories around the world. Based on the natural and socio-economic characteristics of the coastal area of the estuary of the Tien river, it can be seen that the proposed PED meteorological index is suitable for estimating meteorological drought in the study area. Based on emission scenarios 4.5 and 8.5 RCP, this research project establishes a map of meteorological drought scenarios using multivariate regression methods, charting methods, maps, and geographic information systems. The obtained maps show that My Tho City and surrounding areas suffer the highest drought level, in the future, it can reach medium and high levels