Dyslipidemia is a condition associated with increased cholesterol and/or lipids in the blood, and is one of the risk factors leading to cardiovascular disease and stroke. Besides drug treatment, non-pharmacological interventions such as diet and physical activity are the main keys in both prevention and treatment. The rationale for physical activity to improve dyslipidemia through a mechanism of reducing inflammation. Many studies that have focused on the relationship between aerobic exercise and cholesterol found that HDL-C levels are more sensitive to aerobic exercise than both LDL-C and TG. Moreover, non-HDL-C is also an index of current concern and is the treatment target after LDL-C. Of course, aerobic also helps reduce this index. This article gives an overview of the mechanism and the correlation between the intensity of physical activity and detailed blood lipids. Physical activity is still an important non-pharmacological treatment, even for people with disabilities, or with chronic diseases. DOI: 10.59715/pntjmp.3.2.2