Having profound awareness about obesity characteristics will be astrategy to treat obesity and its related diseases. In the current study, we fed micewith high-fat diet for 10 weeks and saw a significant increase in body weight of thehigh-fat diet fed mice compared to the regular diet fed mice. Consequently, thehigh fat-diet fed mice showed significant higher in the weight of the mesentericadipose tissue and the white adipose tissue around brown adipose tissue than didthe regular diet fed mice. Interestingly, there was a markedly increase in size andweight of spleen tissue of the high fat-diet fed mice compared with the regular fedmice. These results indicated that the high-fat diet feeding induced hypertrophicresponse not only in weight and size of several white adipose tissues but also inweight and size of immune tissue such as spleen. Therefore, strategies incontrolling the changes in both white adipose tissue and immune tissue could bebenefits in the battle against obesity and its related metabolic dysfunctions.