Objective: To determine the characteristics of pneumonia caused by SARS-CoV-2 admitted to the Respiratory Department at Thong Nhat Hospital. Methods: This cross-sectional study was conducted on 136 cases of confirmed pneumonia caused by SARS-CoV-2. Diagnosis of pneumonia caused by SARS-CoV-2 was by chest X-ray and/or CT scan. The main results included SARS-CoV-2 pneumonia symptoms and signs, blood test results, and chest x-ray results. Results: There were 80 (58.8%) males and 56 (41.2%) females, mean age was 68.2 ± 10.5, and body mass index was 26.7 ± 6.2 kg/m2. Under 60 years old accounted for 35.3%, followed by 60-70 (22.1%), 71-80 (23.5%) and ≥80 (10.1%). Common comorbidities were hypertension (42.6%), diabetes (40.4%), and chronic lung disease (22.8%). Time onset of pneumonia was 7.5 ± 2.1 days from confirmed COVID-19. The proportion of people with bilateral pneumonia accounted for 72.1%. Common symptoms were fever, cough, shortness of breath, digestive disorders, muscle pain, fatigue, and headache. Oxygen saturation, c-reactive protein, and white blood cell count in the bilateral pneumonia group were 92.1 ± 2.3%, 81.5 ± 32.3 mg/L, and 9 ± 2.4 103/mm3, respectively, which were statistically significantly different compared to the unilateral pneumonia group. The rate of respiratory failure, pulmonary embolism, long hospital stay, and mortality were mainly significant in the group with bilateral pneumonia. Conclusion: Pneumonia caused by SARS-CoV-2 mainly had symptoms of fever, cough, and shortness of breath. Bilateral pneumonia had a predominant rate and more severe clinical and paraclinical manifestations. Complications and mortality rates were higher when bilateral pneumonia was presented. DOI: 10.59715/pntjmp.3.2.13