Introduction: To evaluate and analyze the initial experience of robot-assisted radical nephrectomy (RARN) at Binh Dan Hospital. Patients and methods: We retrospectively analyzed data from 46 patients diagnosed with renal tumors who underwent RARN at Binh Dan Hospital from January 2020 to September 2023. Clinical characteristics, surgical procedures, and complications were recorded and analyzed. Results: 46 patients (29 males, 17 females, median age 58 years, range 48 to 66) were treated. The median tumor diameter was 68 mm, and 24, 19 and 3 patients were classified into cT1, cT2 and cT3, respectively. No patients required conversion to open surgery, and the median operative time and docking time were 158 and 14 minutes, respectively. The median estimated blood loss was 46ml, and no patient required blood transfusion. During the perioperative period, no major complications corresponding to Clavien-Dindo grade ≥3 occurred. Pathological results identified 41 cases of renal cell carcinoma (RCC) and 5 cases of non-RCC. Conclusion: Based on this study, we preliminarily conclude that RARN is a safe and effective method. The perioperative outcomes from initial experiences are promising. Overall, the study helps reinforce the evidence, aiming to position RARN as a promising alternative solution to conventional laparoscopic surgery in cases of complex renal tumors. DOI: 10.59715/pntjmp.3.2.20