Introduction: Electronic cigarettes (E-Cigarettes) are becoming popular among young people. Secondary school students are an age group that is susceptible to infection, however, the problem has not received much attention from families and schools. Objectives: (1) To determine the proportion of good knowledge, good attitude about e-cigarettes of grades 8 and 9 students in Binh Thanh district 2023 and related factors. (2) To determine the proportion of E-cigarettes use of grades 8 and 9 students in Binh Thanh district 2023 and related factors. Materials and Methods: A Cross-sectional study on 758 students in grade 8 and grade 9 at 10 secondary schools in Binh Thanh district from February 2023 to October 2023. Sampling was selected by a self-completed questionnaire, including 6 main factors: personal characteristics, environmental characteristics, knowledge, attitudes, behaviors, and intervention needs to conduct assessment. Results: There are 54.9% of students with good knowledge
92.9% of students have good attitudes about E-Cigarettes. There are 16.8% of students who have used E-Cigarettes at least once. The multivariate model indicate that the factors related to students’ e-cigarette use including ethnicity, academic performance, online shopping, family members/friends/teachers smoking cigarettes/e-cigarettes, and attitudes. Conclusion: The prevalence of e-cigarette use among students in grades 8 and 9 was high. Interventions from the school and family are needed. DOI: 10.59715/pntjmp.3.2.24