The purpose of this paper aims to identify some key components of service quality of domestic tourism programs in Tien Giang province. The paper shows the relationships of tourist satisfaction, loyalty and cultural contact after using tourism service in Tien Giang province based on the qualitative research and quantitative research. Data were obtained from 400 tourists who responded willingly to a questionnaire-based survey. The results of study show factors significantly including tourism infrastructure, natural environment, human resource, safety and security, service price. All of these components and cultural contact have the impact on tourist satisfaction and loyalty.