Saigon River is a major river system and plays an important role in the economic and social development of the Southern key economic region. This paper studies the relationship between canals and the Saigon River. Water quality monitoring data was collected at the Department of Natural Resources and Environment, with 10 parameters (temperature, pH, DO, turbidity, TSS, COD, BOD5, N-NH4, P-PO4, coliform) calculated in the period 2007-2016. The results showed that the Saigon River's water quality has been good and stable water quality in recent years, fluctuating around the level of 80 - used for domestic water supply after appropriate measures have been taken. The water quality in canals flowing into the Saigon River was relatively stable and was at the medium level over years. It is used for irrigation purposes and other similar purposes. The results of the correlation analysis also showed that the RSG1 (at Ba Sang Bridge), RSG2 (Suoi Giua at Suoi Giua Bridge) and RSG6 (Rach Vinh Binh at Din Ky Restaurant) were fair correlated with Saigon river's water quality with the correlation coefficient of 0.3995, 0.4280 and 0.3351 respectively. These results indicated that the monitoring points at Ba Sang Bridge and Suoi Giua at Suoi Giua Bridge and Vinh Binh Canal at Din Ky restaurant affected the Sai Gon river's water quality in the area flowing Binh Duong province.