User satisfaction with information system quality has long been a substantial topic in the literature of information system (IS). Based on the key constructs of IS success model (including system quality and information quality) and technology acceptance model (including perceived ease of use and perceived usefulness), this paper builds and validates a theoretical framework to explain user satisfaction with information system quality. A survey study with AMOS-SEM analysis of 363 users of management information systems in 9 hospitals in HCMC, Vietnam showed that 12 of 14 hypotheses were empirically supported. The findings affirmed the direct influence of system quality, information quality and top management support on perceived ease of use, perceived usefulness and trust, and then on user satisfaction. The results also reinforced the impact of perceived ease of use on perceived usefulness, and the joint influence of perceived usefulness and trust on user satisfaction. The paper is among the first studies, in the healthcare sector, to empirically identify both information system quality and top management support in predicting user acceptance of and satisfaction with information system implementation in organizational settings. The theoretical and managerial implications of the paper were derived.