NGHIÊN CỨU TỔNG HỢP TIỀN CHẤT 2-METHYL-1H-IMIDAZOLE ĐỂ SẢN XUẤT THUỐC KHÁNG SINH METRONIDAZOLE

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Tác giả: Phùng Thị Hương Giang, Phùng Thị Linh Giang, Lê Văn Huỳnh, Loan Nguyễn Thị, Nguyệt Nguyễn Thị, Trần Đức Quang

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Thông tin xuất bản: Tạp chí Khoa học và công nghệ - Trường Đại học Thành Đông, 2024

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ID: 462414

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2-Methyl-1H-imidazole precursor is used to synthesize the antibiotic Metronidazole, which is highly effective against anaerobic bacteria. Metronidazole has been employed as a drug to treat infections caused by bacteria such as Trichomonas, amoebic bacteria, and Helicobacter pylori (HP) bacteria that cause peptic ulcer disease and also pose a risk of leading to stomach cancer. To synthesize the 2-methyl-1Himidazole precursor, the research group identified factors affecting the synthesis process such as: Temperature in the range of 210-220°C
Ethylenediamine/acetic acid ratio of 1/3, and crystallization using ethyl acetate solvent, achieving a synthesis efficiency of 95%. This paper is the result of research on the synthesis of the 2-methyl- 1H-imidazole precursor for the production of the antibiotic Metronidazole. The research results provide a scientific basis for the practical application of production technology processes, with the aim of contributing to the self-sufficient development of pharmaceutical raw materials in Vietnam."Tiền chất 2-methyl-1H-imidazole được sử dụng để tổng hợp thuốc kháng sinh Metronidazole, loại chất kháng sinh này có khả năng chống các vi khuẩn yếm khí rất hiệu quả. Metronidazole đã được đưa vào sử dụng làm thuốc để điều trị các bệnh nhiễm khuẩn do các vi khuẩn gây ra như: Trichomonas, vi khuẩn amip và vi khuẩn HP gây bệnh viêm loét dạ dày, tá tràng và cũng là nguy cơ dẫn tới ung thư dạ dày. Để tổng hợp tiền chất 2-methyl-1H-imidazole nhóm nghiên cứu đã tìm ra các yếu tố ảnh hưởng đến quá trình tổng hợp như: Nhiệt độ trong khoảng 210 – 220oC
Tỷ lệ lệ ethylediamin / acid acetic bằng 1/3, Kết tinh bằng dung môi etyl axetat, lúc này hiệu suất tổng hợp đạt 95%. Bài báo này là kết quả nghiên cứu tổng hợp tiền chất 2-methyl-1H-imidazole để sản xuất thuốc kháng sinh metronidazole. Kết quả nghiên cứu là cơ sở khoa học cho việc áp dụng vào thực tiễn các quá trình công nghệ sản xuất, với mong muốn góp phần tự chủ phát triển nguồn nguyên liệu dược tại Việt Nam.

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