Pharmacological ascorbate combined with rucosopasem selectively radio-chemo-sensitizes NSCLC via generation of H

• Tác giả: B G Allen, K Bayanbold, R A Beardsley, G R Buettner, J M Caster, M A Fath, B N George, S T Johnson, A L Kalen, J L Keene, C F Pulliam, D P Riley, S Sho, M Singhania, S R Solst, D R Spitz, B A Wagner
• Ngôn ngữ: eng
• Ký hiệu phân loại: 788.53 *Cors anglais (English horns)
• Thông tin xuất bản: Netherlands : Redox biology , 2025
• Bộ sưu tập: NCBI
• ID: 462658

Tóm tắt

Differences in cancer and normal cell oxidative metabolism provide a unique therapeutic opportunity for developing combined modality approaches with redox-active small molecules as radio-chemosensitizers that are well-tolerated by normal tissues. Pentaazamacrocyclic Mn (II)-containing (MnPAM) superoxide dismutase (SOD) mimetics and pharmacological ascorbate given IV to achieve [mM] plasma levels (pharmacological ascorbate: P-AscH‾) have been shown to act individually as cancer cell radio- and chemosensitizers via the generation of H