Gravimetric drop-on-demand inkjet deposition for imaging phantoms with traceable activity.

• Tác giả: Bryan P Bednarz, Denis E Bergeron, Larry A DeWerd, Ryan P Fitzgerald, Sean P Jollota, Ohyun Kwon, Brian W Miller, Svetlana Nour, Jeffrey L Radtke, R Michael Verkouteren
• Ngôn ngữ: eng
• Ký hiệu phân loại: 727.9 Other buildings for educational and research purposes
• Thông tin xuất bản: England : Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine , 2025
• Bộ sưu tập: NCBI
• ID: 462760

Tóm tắt

Autoradiography is an important tool in preclinical investigations with alpha-emitting radionuclides. Precise biodistribution studies establish the effectiveness of biological "targeting" strategies, assuring that the promise of targeted alpha therapy (TAT) is realized. There is a need for calibration and test objects (phantoms) to evaluate and support precise autoradiography. Leveraging recent advances in drop-on-demand inkjet methods, we demonstrate the preparation of an autoradiography phantom with activity traceable to primary measurements. With digital autoradiography we demonstrate spatial resolution less than 20 μm. Corrections required to calibrate a digital autoradiography system for activity are discussed.