Materials that can visually report changes in the surrounding environments are essential for future portable sensors that monitor temperature and detect hazardous chemicals. Ideal responsive materials for optical sensors are defined by a rapid response and readout, high selectivity, the ability to operate at room temperature, and simple microfabrication. However, because of the lack of viable materials and approaches, compact, passive, and multipurpose practical devices are still beyond reach. To address this challenge, we develop a methodology to fabricate colored and responsive micropixels printed by digital light projection lithography on gold substrates. These structures are made by polymeric Liquid Crystalline Networks (LCNs) whose birefringence and external stimuli responsiveness allow for micrometric devices with visual and fast response that we here apply to a few applications. First, we show how varying the projected geometrical shape can become an effective tool to engineer symmetric disclination lines in the liquid crystal order. Depending on the thickness of the micropixels, LCNs give rise to a birefringence color under polarized light or a structural color under white light due to thin-film interference. By exposing the micropatterns to temperature variation and solvents, we demonstrate a real-time optical temperature detection and differentiation between selected organic chemicals. The proposed materials and fabrication method could be scaled up and extended to roll-to-roll printing, enabling future real-life applications of liquid crystalline polymers in affordable microdevices and optical sensors with a net advantage with respect to traditional lithographic techniques in terms of fabrication speeds and costs.