FKBP51 inhibition ameliorates neurodegeneration and motor dysfunction in the neuromelanin-SNCA mouse model of Parkinson's disease.

• Tác giả: Maria Angeles Burrell, Mar Cuadrado-Tejedor, Maria Espelosin, Marta Garcia-Gomara, Ana Garcia-Osta, Jose Luis Lanciego, Naroa Legarra-Marcos, Maria Rosario Luquin, Irene Marcilla, Alberto Perez-Mediavilla, Elvira Rojas-de-Miguel, Maria Serena
• Ngôn ngữ: eng
• Ký hiệu phân loại: 302.17 Social dysfunction
• Thông tin xuất bản: United States : Molecular therapy : the journal of the American Society of Gene Therapy , 2025
• Bộ sưu tập: NCBI
• ID: 463477

Tóm tắt

Parkinson's disease (PD) is characterized by the loss of neuromelanin (NM)-containing dopaminergic (DA) neurons in the substantia nigra (SN) pars compacta (SNpc) and the buildup of α-synuclein (α-syn) inclusions, called Lewy bodies. To investigate the roles of NM and α-syn in DA neuron degeneration, we modeled PD by inducing NM accumulation in a humanized α-syn mouse model (Snca