ROS anchor PAMPs-mediated extracellular HMGB1 self-association and its dimerization enhances pro-inflammatory signaling.

• Tác giả: Seoyeon Choi, Myeonggil Han, Jeonghwa Kim, Man Sup Kwak, Yong Joon Lee, In Ho Park, Jeon-Soo Shin
• Ngôn ngữ: eng
• Ký hiệu phân loại: 070.48346 Journalism
• Thông tin xuất bản: Netherlands : Redox biology , 2025
• Bộ sưu tập: NCBI
• ID: 463592

Tóm tắt

Many cellular proteins form homo- or hetero-oligomeric complexes through dimerization, and ligand oligomerization is crucial for inducing receptor oligomerization. Intermolecular disulfide bond formation is critical for protein oligomerization that regulates biological functions. HMGB1 is a nuclear protein that acts as a DAMP when secreted. HMGB1 is redox-sensitive, contains three cysteines: Cys