Altered thermal preference by preoptic estrogen receptor alpha neurons in postpartum females.

• Tác giả: Jonathan C Bean, Lulu Chen, Kristine M Conde, Yue Deng, Benjamin P Eappen, Bing Feng, Junying Han, Yang He, Yanlin He, Yongxiang Li, Hailan Liu, Hesong Liu, Qingzhuo Liu, Taylor Smiley, Darah Ave Threat, Longlong Tu, Chunmei Wang, Mengjie Wang, Nathan Xu, Pingwen Xu, Yongjie Yang, Na Yin, Meng Yu, Tianshu Zeng, Nan Zhang, Qianru Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 388.3222 *Vehicular transportation
• Thông tin xuất bản: Germany : Molecular metabolism , 2025
• Bộ sưu tập: NCBI
• ID: 463595

Tóm tắt

 OBJECTIVE: This study aims to investigate how reproductive experience (RE) alters thermal preference and thermoregulation in female mice, with a focus on estrogen receptor alpha (ERα)-expressing neurons in the preoptic area (POA). METHODS: Thermal preference and body temperature were measured in female mice with and without RE, and virgin female mice with selective deletion of ERα from the POA (ERα RESULTS: We showed that female mice prefer a cooler environment starting from late pregnancy and persisting long term postpartum. Female mice with RE (>
 4 weeks post-weaning) displayed lower body temperature and a lower thermal preferred temperature, and lost preference for warm environments (30 °C) but preserved avoidance of cold environments (15 °C). This was associated with a significant decrease in the number of ERα CONCLUSION: Our results support that the thermosensing ability and estrogenic effects in ERα