5-Fluorouracil induces hair loss by inhibiting β-catenin signaling and angiogenesis.

• Tác giả: Hye-Jin Boo, Youn Kyung Choi, Sang-Chul Han, Jin Won Hyun, Hee-Kyoung Kang, Jung-Il Kang, Young-Sang Koh, Jaeseong Oh, Eun-Sook Yoo
• Ngôn ngữ: eng
• Thông tin xuất bản: Ireland : Chemico-biological interactions , 2025
• Bộ sưu tập: NCBI
• ID: 464010

Tóm tắt

Chemotherapy-induced alopecia (CIA) is a side effect of the anticancer drug 5-fluorouracil (5-FU). However, the mechanism of action in hair follicle cells is unclear. This study investigated the mechanism of action of 5-FU on the hair cycle and growth in vitro and in vivo. Intraperitoneal injection of 5-FU into C57BL/6 mice delayed anagen initiation, resulting in small hair follicles. 5-FU inhibited angiogenesis by reducing cluster of differentiation 31