In vitro human skin absorption of ethyl salicylate, pentyl salicylate, and (Z)-3-hexenyl salicylate from topical formulations: Effects on permeation and distribution.

• Tác giả: Anne Marie Api, Arianna P Bartlett, Sophie E Davies, Darren M Green, A Christian Jones, Kaushal Joshi, Sophie G Stocks
• Ngôn ngữ: eng
• Ký hiệu phân loại: 296.1146 Sources
• Thông tin xuất bản: England : Toxicology in vitro : an international journal published in association with BIBRA , 2025
• Bộ sưu tập: NCBI
• ID: 464016

Tóm tắt

In vitro human skin permeation and distribution of the fragrance materials ethyl salicylate (CAS 118-61-6, ES), (Z)-3-hexenyl salicylate (CAS 65405-77-8, HS) and pentyl salicylate (CAS 2050-08-0, PS) from separate 0.5 % (w/w) cream formulations were determined under unoccluded and occluded conditions for 24 h. For PS only, a 0.5 % (w/v) solution in 70/30 (v/v) ethanol/water was also assessed. Consumer relevant finite formulation doses were applied (5 mg/cm