Phospho-tau serine-262 and serine-356 as biomarkers of pre-tangle soluble tau assemblies in Alzheimer's disease.

• Tác giả: Eric E Abrahamson, Kaj Blennow, Yijun Chen, Ivana Del Popolo, Douglas Galasko, Fernando Gonzalez-Ortiz, Emily Hill, Milos D Ikonomovic, Tohidul Islam, Przemysław R Kac, Thomas K Karikari, Hlin Kvartsberg, Tammaryn Lashley, Victoria Mitchell, Maria Olsson, Tharick A Pascoal, Nesrine Rahmouni, Abbie Richardson, Pedro Rosa-Neto, Anuradha Sehrawat, Stijn Servaes, Emma Sjons, Denis S Smirnov, Joseph Therriault, Cécile Tissot, Mark J Wall, Xuemei Zeng, Henrik Zetterberg
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.831 *Alzheimer disease
• Thông tin xuất bản: United States : Nature medicine , 2025
• Bộ sưu tập: NCBI
• ID: 464364

Tóm tắt

Patients with Alzheimer's disease (AD) with little or no quantifiable insoluble brain tau neurofibrillary tangle (NFT) pathology demonstrate stronger clinical benefits of therapies than those with advanced NFTs. The formation of NFTs can be prevented by targeting the intermediate soluble tau assemblies (STAs). However, biochemical understanding and biomarkers of STAs are lacking. We show that Tris-buffered saline-soluble tau aggregates from autopsy-verified AD brain tissues include the core sequence ~tau