Rational engineering of isoform-specific hSULT1E1 fluorogenic substrates for functional analysis and inhibitor screening.

• Tác giả: Lin Chen, Yufan Fan, Guangbo Ge, Tony D James, Xiaoting Niu, Mengru Sun, Zhenhao Tian, Luling Wu, Hairong Zeng, Bei Zhao, Guanghao Zhu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.962 *Diseases due to endoparasites
• Thông tin xuất bản: England : Biosensors & bioelectronics , 2025
• Bộ sưu tập: NCBI
• ID: 464388

Tóm tắt

Human estrogen sulfotransferase (hSULT1E1), an important conjugative enzyme, plays crucial roles in both estrogen homeostasis and xenobiotic metabolism. Herein, a rational substrate engineering strategy was adopted to construct highly specific fluorogenic substrates for hSULT1E1. In the 1