OBJECTIVES: To explore the long-term effect of intelligent first-aid training based on virtual reality (VR) technology on cardiopulmonary resuscitation (CPR) skill proficiency. METHODS: The convenience sampling method was used to select a total of 100 non-medical volunteers from Nanchang, China, and this cohort was randomized to either the VR training group (VR group) or the traditional simulation scenario training group (traditional group). Relevant data were collected for comparative analysis. Participants were evaluated by measuring mean chest compression depth, chest compression pauses time, the proportion of compressions with correct compression depth, mean chest compression rate, and mean ventilation volume. RESULTS: After initial training, the two groups of participants showed similar results in terms of chest compression depth and chest compression rate. There were significant differences in chest compression pauses time, proportion of compressions with correct compression depth, and ventilation volume ( CONCLUSIONS: Training with VR can significantly improve CPR knowledge and skill levels and help learners master and maintain high-quality CPR skills.