The latest figures for TB are a sombre reminder that we need to accelerate progress to eradicate this disease. We are, therefore, launching a series of articles that bring the focus back onto TB elimination. We begin with an article that highlights the factors that have helped to reduce mortality due to HIV/AIDS and the lessons that might be applied to TB control. Then, the authors of a 'Regional Perspective' describe the current strategy to reduce the burden of TB in the Western Pacific Region. The authors critically review the progress made, and the remaining challenges, allowing them to propose additional elements to improve TB control. We anticipate that the series will highlight many commonalities, but also provide ideas for innovative solutions, and provoke discussion on how best to move forward.