A novel bifunctional inhibitor of protease and α-amylase from Clitorea ternatea restricts the growth and development in Spodoptera frugiperda.

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Tác giả: Neha V Deshpande, Pratiksha M Dongare, Ashok P Giri, Rakesh S Joshi, Varsha A Madage, Pankaj K Pawar

Ngôn ngữ: eng

Ký hiệu phân loại: 302.222 Nonverbal communication

Thông tin xuất bản: Netherlands : International journal of biological macromolecules , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 468953

An inhibitor molecule capable of inhibiting a wide range of digestive enzymes without affecting endogenous enzymes is always desirable. We report characterization of CteTAI (M.W. 14 kDa), a bifunctional inhibitor (BFI) protein from the seeds of Clitoria ternatea capable of inhibiting trypsin and α-amylase. It retains trypsin inhibition activity up to 60 °C and α-amylase inhibition up to 40 °C. Trypsin inhibition is stable across pH 1-12, while α-amylase inhibition is stable between pH 3-7. CteTAI is a noncompetitive inhibitor of trypsin and an uncompetitive inhibitor of α-amylase. It selectively inhibits proteases and α-amylases from various sources, without affecting α-amylase from human saliva and Bacillus spp. Proteomic analysis identified CteTAI as a bifunctional inhibitor exhibiting 41 % similarity to a bifunctional inhibitor from Sesbania bispinosa. Feeding Spodoptera frugiperda larvae with CteTAI-infused diet impaired energy metabolism, resulting in undernourished larvae and malformed adults incapable of flight and mating. Key nutritional indices (RGR, RCR, %ECI, %FDI) were severely reduced, indicating that CteTAI disrupts growth and development by inhibiting multiple protease and α-amylase isoforms. Biochemical characterization of newly identified CteTAI suggests its potential application in crop protection.
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